Currently many biological databases have been developed and became an important toolbox for every scientist in research and academic purpose. Searching a sequence homologue of either Protein, DNA or to know the novelty of a sequence, one needs to do a sequence search against available databases. Similarly, searching for Open Reading Frame, structure, functional, regulatory sequences and repeated elements, we also need to search our query against different available databases. As biological data is increasing with the passage of time, its tremendous growth requires a searching and access system to retrieve useful information. In biological data, three retrieval systems are widely used relevant to a scientific need, it includes: Entrez, Sequence Retrieval System also known as SRS and DBGET. These retrieval systems let its user a text search against multiple molecular databases and also provides useful relevant information in the forms of links either internal or external to our qu...